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Target
Alkaline phosphatase, placental type
Ligand
BDBM50150071
Substrate
n/a
Meas. Tech.
ChEBML_1559915
pH
7.8±n/a
IC50
>400000±n/a nM
Comments
extracted
Citation
 Marquès, S; Buchet, R; Popowycz, F; Lemaire, M; Mebarek, S Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization. Bioorg Med Chem Lett 26:1457-9 (2016) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM50150071
Synonyms:
CHEMBL3774946
Type:
Small organic molecule
Emp. Form.:
C13H12N2O2S
Mol. Mass.:
260.312
SMILES:
OC(Cn1ccsc1=N)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: