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TargetAlkaline phosphatase placental type
LigandBDBM50150070
Substrate/Competitorn/a
Meas. Tech.ChEBML_1559915
pH7.8±n/a
IC50>400000±n/a nM
Commentsextracted
Citation Marquès, SBuchet, RPopowycz, FLemaire, MMebarek, S Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization. Bioorg Med Chem Lett26:1457-9 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase placental type
Name:Alkaline phosphatase placental type
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:57950.65
Organism:Homo sapiens (Human)
Description:ChEMBL_1506090
Residue:535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50150070
NameBDBM50150070
Synonyms:CHEMBL3774470
TypeSmall organic molecule
Emp. Form.C13H10N2OS
Mol. Mass.242.296
SMILESC1C(N=C2SC=CN12)c1cc2ccccc2o1 |c:5,t:2|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a