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Target
Lysine-specific demethylase 4E
Ligand
BDBM50149924
Substrate
n/a
Meas. Tech.
ChEMBL_1558375 (CHEMBL3772967)
IC50
398±n/a nM
Citation
 Westaway, SM; Preston, AG; Barker, MD; Brown, F; Brown, JA; Campbell, M; Chung, CW; Drewes, G; Eagle, R; Garton, N; Gordon, L; Haslam, C; Hayhow, TG; Humphreys, PG; Joberty, G; Katso, R; Kruidenier, L; Leveridge, M; Pemberton, M; Rioja, I; Seal, GA; Shipley, T; Singh, O; Suckling, CJ; Taylor, J; Thomas, P; Wilson, DM; Lee, K; Prinjha, RK Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J Med Chem 59:1370-87 (2016) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4E
Synonyms:
2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:
Enzyme
Mol. Mass.:
56815.71
Organism:
Homo sapiens (Human)
Description:
B2RXH2
Residue:
506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
  
Inhibitor
Name:
BDBM50149924
Synonyms:
CHEMBL3769511
Type:
Small organic molecule
Emp. Form.:
C15H14N4O2
Mol. Mass.:
282.2973
SMILES:
CC(C)c1ccc(Oc2nc3cnccc3c(=O)[nH]2)cn1
Structure:
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