Target
Lysine-specific demethylase 4D
Ligand
BDBM50149925
Substrate
n/a
Meas. Tech.
ChEMBL_1558374 (CHEMBL3772966)
IC50
316±n/a nM
Citation
 Westaway, SMPreston, AGBarker, MDBrown, FBrown, JACampbell, MChung, CWDrewes, GEagle, RGarton, NGordon, LHaslam, CHayhow, TGHumphreys, PGJoberty, GKatso, RKruidenier, LLeveridge, MPemberton, MRioja, ISeal, GAShipley, TSingh, OSuckling, CJTaylor, JThomas, PWilson, DMLee, KPrinjha, RK Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J Med Chem 59:1370-87 (2016) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4D
Synonyms:
JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:
PROTEIN
Mol. Mass.:
58627.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102441
Residue:
523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
  
Inhibitor
Name:
BDBM50149925
Synonyms:
CHEMBL3770740
Type:
Small organic molecule
Emp. Form.:
C13H8ClN3O3
Mol. Mass.:
289.674
SMILES:
Oc1cc(Oc2nc3cnccc3c(=O)[nH]2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: