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Target
Presenilin-1
Ligand
BDBM50150519
Substrate
n/a
Meas. Tech.
ChEMBL_1558617 (CHEMBL3774270)
IC50
29±n/a nM
Citation
 Shi, J; Zuev, D; Xu, L; Lentz, KA; Grace, JE; Toyn, JH; Olson, RE; Macor, JE; Thompson, LA Design and optimization of tricyclic gamma-secretase modulators. Bioorg Med Chem Lett 26:1498-502 (2016) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50150519
Synonyms:
CHEMBL3769487
Type:
Small organic molecule
Emp. Form.:
C22H23N7O
Mol. Mass.:
401.4643
SMILES:
CNc1nc(Cc2ccccc2)nc(Nc2ccc(c(OC)c2)-n2cnc(C)c2)n1
Structure:
Search PDB for entries with ligand similarity: