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Target
Lysine-specific demethylase 4D
Ligand
BDBM50151399
Substrate
n/a
Meas. Tech.
ChEMBL_1561042 (CHEMBL3776338)
IC50
4200±n/a nM
Citation
 Korczynska, M; Le, DD; Younger, N; Gregori-Puigjané, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, RP; Iwasa, E; Pollock, SB; Ortiz Torres, I; Oppermann, U; Shoichet, BK; Fujimori, DG Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem 59:1580-98 (2016) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4D
Synonyms:
JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:
PROTEIN
Mol. Mass.:
58627.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102441
Residue:
523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
  
Inhibitor
Name:
BDBM50151399
Synonyms:
CHEMBL3775380
Type:
Small organic molecule
Emp. Form.:
C15H14N2O5
Mol. Mass.:
302.2821
SMILES:
COCC(=O)Nc1ccc(O)c(c1)-c1cc(ccn1)C(O)=O
Structure:
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