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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50152081
Substrate
n/a
Meas. Tech.
ChEMBL_1564511 (CHEMBL3783357)
IC50
57±n/a nM
Citation
 Huang, Y; Liu, J; Yan, L; Zheng, W Simple N(e)-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition. Bioorg Med Chem Lett 26:1612-7 (2016) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50152081
Synonyms:
CHEMBL3781129
Type:
Small organic molecule
Emp. Form.:
C41H74N10O8S2
Mol. Mass.:
899.218
SMILES:
CSCC[C@H](NC(=O)[C@@H]1CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(C)=S)C(=O)N1)C(N)=O |r|
Structure:
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