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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7918
Substrate
n/a
Meas. Tech.
ChEMBL_1563857 (CHEMBL3784463)
IC50
5300±n/a nM
Citation
 Li, M; Dong, Y; Yu, X; Zou, Y; Zheng, Y; Bu, X; Quan, J; He, Z; Wu, H Inhibitory effect of flavonoids on human glutaminyl cyclase. Bioorg Med Chem 24:2280-6 (2016) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7918
Synonyms:
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea | 1-(3-(1H-Imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea | 1-alkylimidazole thiourea deriv. 53 | PBD150
Type:
Small organic molecule
Emp. Form.:
C15H20N4O2S
Mol. Mass.:
320.41
SMILES:
COc1ccc(NC(=S)NCCCn2ccnc2)cc1OC
Structure:
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