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Target
Quinolone resistance protein NorA
Ligand
BDBM50153186
Substrate
n/a
Meas. Tech.
ChEMBL_1562415 (CHEMBL3778151)
IC50
4800±n/a nM
Citation
 Lepri, S; Buonerba, F; Goracci, L; Velilla, I; Ruzziconi, R; Schindler, BD; Seo, SM; Kaatz, GW; Cruciani, G Indole Based Weapons to Fight Antibiotic Resistance: A Structure-Activity Relationship Study. J Med Chem 59:867-91 (2016) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50153186
Synonyms:
CHEMBL3774520
Type:
Small organic molecule
Emp. Form.:
C27H33FN2O3
Mol. Mass.:
452.5609
SMILES:
CCOC(=O)c1c(C)n(Cc2ccccc2F)c2ccc(OCCCN3CCCCC3)cc12
Structure:
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