Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM50153493
Substrate
n/a
Meas. Tech.
ChEMBL_1560863 (CHEMBL3778935)
Ki
41±n/a nM
Citation
Erchegyi, J; Wang, L; Gulyas, J; Samant, M; Perrin, MH; Lewis, K; Miller, C; Vaughan, J; Donaldson, C; Fischer, W; Low, W; Yakabi, S; Karasawa, H; Taché, Y; Rivier, C; Rivier, J Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins). J Med Chem 59:854-66 (2016) [PubMed] Article
More Info.:
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R-2 | CRF-R2 | CRF-RB | CRFR-2 | CRFR2_MOUSE | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:
PROTEIN
Mol. Mass.:
47628.12
Organism:
Mus musculus
Description:
ChEMBL_51276
Residue:
411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
Inhibitor
Name:
BDBM50153493
Synonyms:
CHEMBL3775707
Type:
Small organic molecule
Emp. Form.:
C191H306N54O52S2
Mol. Mass.:
4254.934
SMILES:
CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)NC1CCSSCCC(NC(=O)[C@@H](Cc2ccc(NC(N)=O)cc2)NC(=O)C(Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r|