Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50154910
Substrate
n/a
Meas. Tech.
ChEMBL_1562114 (CHEMBL3779656)
IC50
1010±n/a nM
Citation
 Kumar, GB; Nayak, VL; Sayeed, IB; Reddy, VS; Shaik, AB; Mahesh, R; Baig, MF; Shareef, MA; Ravikumar, A; Kamal, A Design, synthesis of phenstatin/isocombretastatin-oxindole conjugates as antimitotic agents. Bioorg Med Chem 24:1729-40 (2016) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50154910
Synonyms:
CHEMBL3775353
Type:
Small organic molecule
Emp. Form.:
C26H22FNO6
Mol. Mass.:
463.4544
SMILES:
COc1ccc(cc1\C=C1\C(=O)Nc2ccc(F)cc12)C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
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