Reaction Details Report a problem with these data
Target
Cyclin-C
Ligand
BDBM50155240
Substrate
n/a
Meas. Tech.
ChEMBL_1562017 (CHEMBL3779191)
IC50
5.0±n/a nM
Citation
 Schiemann, K; Mallinger, A; Wienke, D; Esdar, C; Poeschke, O; Busch, M; Rohdich, F; Eccles, SA; Schneider, R; Raynaud, FI; Czodrowski, P; Musil, D; Schwarz, D; Urbahns, K; Blagg, J Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. Bioorg Med Chem Lett 26:1443-51 (2016) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50155240
Synonyms:
CHEMBL3775773
Type:
Small organic molecule
Emp. Form.:
C23H21F2N5O
Mol. Mass.:
421.4425
SMILES:
Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCC(F)(F)C2)cc1
Structure:
Search PDB for entries with ligand similarity: