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Target
Mitogen-activated protein kinase 12
Ligand
BDBM50156129
Substrate
n/a
Meas. Tech.
ChEMBL_1563502 (CHEMBL3783187)
IC50
354±n/a nM
Citation
 Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma. J Med Chem 59:1727-46 (2016) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 12
Synonyms:
ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma
Type:
Protein
Mol. Mass.:
41938.69
Organism:
Homo sapiens (Human)
Description:
P53778
Residue:
367
Sequence:
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL
  
Inhibitor
Name:
BDBM50156129
Synonyms:
CHEMBL3782036
Type:
Small organic molecule
Emp. Form.:
C35H38N6O4
Mol. Mass.:
606.714
SMILES:
COCC(=O)Nc1cnccc1CCOc1ccc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)c2ccccc12
Structure:
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