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TargetSteroid 17-alpha-hydroxylase/17,20 lyase
LigandBDBM50156282
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1563728
IC50 3.0±n/a nM
Citation Huang, AJayaraman, LFura, AVite, GDTrainor, GLGottardis, MMSpires, TESpires, VMRizzo, CAObermeier, MTElzinga, PATodderud, GFan, YNewitt, JABeyer, SMZhu, YWarrack, BMGoodenough, AKTebben, AJDoweyko, AMGold, DLBalog, A Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett7:40-5 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Steroid 17-alpha-hydroxylase/17,20 lyase
Name:Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:17-alpha-hydroxyprogesterone aldolase | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:PROTEIN
Mol. Mass.:57634.34
Organism:Macaca fascicularis
Description:ChEMBL_116757
Residue:508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVIS
LICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRN
DLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNP
KVVFLIDSFKVKIKVRQAWREAQAEGST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50156282
NameBDBM50156282
Synonyms:CHEMBL3780847
TypeSmall organic molecule
Emp. Form.C24H31NO
Mol. Mass.349.509
SMILES[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)C1CC[C@@]1(C)C2CC=C1c1cccnc1 |r,c:22,t:3|
Structure
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