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Target
Cytochrome P450 26B1
Ligand
BDBM50157720
Substrate
n/a
Meas. Tech.
ChEMBL_1567868 (CHEMBL3789263)
IC50
6200±n/a nM
Citation
 Diaz, P; Huang, W; Keyari, CM; Buttrick, B; Price, L; Guilloteau, N; Tripathy, S; Sperandio, VG; Fronczek, FR; Astruc-Diaz, F; Isoherranen, N Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. J Med Chem 59:2579-95 (2016) [PubMed]  Article 
Target
Name:
Cytochrome P450 26B1
Synonyms:
CP26B_HUMAN | CYP26A2 | CYP26A2 | CYP26B1 | Cytochrome P450 26A2 | Cytochrome P450 26B1 | Cytochrome P450 retinoic acid-inactivating 2 | Cytochrome P450RAI-2 | P450RAI2 | Retinoic acid-metabolizing cytochrome
Type:
PROTEIN
Mol. Mass.:
57525.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115648
Residue:
512
Sequence:
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
  
Inhibitor
Name:
BDBM50157720
Synonyms:
CHEMBL3786340
Type:
Small organic molecule
Emp. Form.:
C23H28O4S
Mol. Mass.:
400.531
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)c1ccc(CCC(O)=O)cc1
Structure:
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