Reaction Details Report a problem with these data
Target
Cytochrome P450 26B1
Ligand
BDBM50253810
Substrate
n/a
Meas. Tech.
ChEMBL_1567868 (CHEMBL3789263)
IC50
0.460000±n/a nM
Citation
 Diaz, P; Huang, W; Keyari, CM; Buttrick, B; Price, L; Guilloteau, N; Tripathy, S; Sperandio, VG; Fronczek, FR; Astruc-Diaz, F; Isoherranen, N Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. J Med Chem 59:2579-95 (2016) [PubMed]  Article 
Target
Name:
Cytochrome P450 26B1
Synonyms:
CP26B_HUMAN | CYP26A2 | CYP26A2 | CYP26B1 | Cytochrome P450 26A2 | Cytochrome P450 26B1 | Cytochrome P450 retinoic acid-inactivating 2 | Cytochrome P450RAI-2 | P450RAI2 | Retinoic acid-metabolizing cytochrome
Type:
PROTEIN
Mol. Mass.:
57525.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115648
Residue:
512
Sequence:
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
  
Inhibitor
Name:
BDBM50253810
Synonyms:
CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine | R-115866 | R115866 | US9963439, Talarozole
Type:
Small organic molecule
Emp. Form.:
C21H23N5S
Mol. Mass.:
377.506
SMILES:
CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1
Structure:
Search PDB for entries with ligand similarity: