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Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50158371
Substrate
n/a
Meas. Tech.
ChEMBL_1564181 (CHEMBL3784078)
IC50
69000±n/a nM
Citation
 Ferreira de Freitas, R; Eram, MS; Szewczyk, MM; Steuber, H; Smil, D; Wu, H; Li, F; Senisterra, G; Dong, A; Brown, PJ; Hitchcock, M; Moosmayer, D; Stegmann, CM; Egner, U; Arrowsmith, C; Barsyte-Lovejoy, D; Vedadi, M; Schapira, M Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J Med Chem 59:1176-83 (2016) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50158371
Synonyms:
CHEMBL3780738
Type:
Small organic molecule
Emp. Form.:
C12H13NS
Mol. Mass.:
203.303
SMILES:
CNCc1cccc(c1)-c1ccsc1
Structure:
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