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Target
Scavenger receptor class B member 1
Ligand
BDBM50159550
Substrate
n/a
Meas. Tech.
ChEMBL_1569538 (CHEMBL3789894)
IC50
40±n/a nM
Citation
 Sparks, SM; Zhou, H; Generaux, C; Harston, L; Moncol, D; Jayawickreme, C; Parham, J; Condreay, P; Rimele, T Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration. Bioorg Med Chem Lett 26:1901-4 (2016) [PubMed]  Article 
Target
Name:
Scavenger receptor class B member 1
Synonyms:
CD36 and LIMPII analogous 1 | CD36 antigen-like 1 | CD36L1 | CD_antigen=CD36 | CLA-1 | CLA1 | Collagen type I receptor, thrombospondin receptor-like 1 | SCARB1 | SCRB1_HUMAN | SR-BI | SRB1
Type:
PROTEIN
Mol. Mass.:
60889.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_872680
Residue:
552
Sequence:
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
  
Inhibitor
Name:
BDBM50159550
Synonyms:
CHEMBL3785336
Type:
Small organic molecule
Emp. Form.:
C36H50N4O9S
Mol. Mass.:
714.869
SMILES:
COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCN(CCO)CCO)C(C)(C)C
Structure:
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