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Target
Proteasome subunit beta type-5
Ligand
BDBM50160868
Substrate
n/a
Meas. Tech.
ChEMBL_1567337 (CHEMBL3789477)
IC50
1.6±n/a nM
Citation
 Shi, J; Lei, M; Wu, W; Feng, H; Wang, J; Chen, S; Zhu, Y; Hu, S; Liu, Z; Jiang, C Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed fromaa- andaß-amino acids. Bioorg Med Chem Lett 26:1958-62 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50160868
Synonyms:
CHEMBL499504
Type:
Small organic molecule
Emp. Form.:
C25H33BN2O4
Mol. Mass.:
436.352
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2CCCCc12)B(O)O |r|
Structure:
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