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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50161847
Substrate
n/a
Meas. Tech.
ChEMBL_1572137 (CHEMBL3796861)
IC50
460±n/a nM
Citation
 Igawa, H; Takahashi, M; Shirasaki, M; Kakegawa, K; Kina, A; Ikoma, M; Aida, J; Yasuma, T; Okuda, S; Kawata, Y; Noguchi, T; Yamamoto, S; Fujioka, Y; Kundu, M; Khamrai, U; Nakayama, M; Nagisa, Y; Kasai, S; Maekawa, T Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition. Bioorg Med Chem 24:2486-503 (2016) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50161847
Synonyms:
CHEMBL3793395
Type:
Small organic molecule
Emp. Form.:
C25H24FN3O2
Mol. Mass.:
417.4754
SMILES:
Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CCCC1
Structure:
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