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Target
Oxidized purine nucleoside triphosphate hydrolase
Ligand
BDBM50352564
Substrate
n/a
Meas. Tech.
ChEMBL_1572469 (CHEMBL3796329)
IC50
330±n/a nM
Citation
 Papeo, G MutT Homolog 1 (MTH1): The Silencing of a Target. J Med Chem 59:2343-5 (2016) [PubMed]  Article 
Target
Name:
Oxidized purine nucleoside triphosphate hydrolase
Synonyms:
7,8-dihydro-8-oxoguanine triphosphatase | 8ODP_HUMAN | MTH1 | MutT homolog 1 protein (MTH1) | NUDT1
Type:
Protein
Mol. Mass.:
22514.81
Organism:
Homo sapiens (Human)
Description:
P36639
Residue:
197
Sequence:
MYWSNQITRRLGERVQGFMSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
  
Inhibitor
Name:
BDBM50352564
Synonyms:
CHEMBL1825141
Type:
Small organic molecule
Emp. Form.:
C21H22Cl2FN5O
Mol. Mass.:
450.337
SMILES:
C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r|
Structure:
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