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TargetBranched-chain-amino-acid aminotransferase, mitochondrial
LigandBDBM50162498
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1570254
IC50 63096±n/a nM
Citation Borthwick, JAAncellin, NBertrand, SMBingham, RPCarter, PSChung, CWChurcher, IDodic, NFournier, CFrancis, PLHobbs, AJamieson, CPickett, SDSmith, SESomers, DOSpitzfaden, CSuckling, CJYoung, RJ Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J Med Chem59:2452-67 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Branched-chain-amino-acid aminotransferase, mitochondrial
Name:Branched-chain-amino-acid aminotransferase, mitochondrial
Synonyms:BCAT(m) | BCAT2 | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18
Type:PROTEIN
Mol. Mass.:44297.81
Organism:Homo sapiens (Human)
Description:ChEMBL_109874
Residue:392
Sequence:
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
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BDBM50162498
NameBDBM50162498
Synonyms:CHEMBL1578072
TypeSmall organic molecule
Emp. Form.C9H8N2O3S
Mol. Mass.224.236
SMILESCc1c(sc2ncn(C)c(=O)c12)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a