Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50163501
Substrate
n/a
Meas. Tech.
ChEMBL_1572290 (CHEMBL3795821)
IC50
70±n/a nM
Citation
 Igawa, H; Takahashi, M; Ikoma, M; Kaku, H; Kakegawa, K; Kina, A; Aida, J; Okuda, S; Kawata, Y; Noguchi, T; Hotta, N; Yamamoto, S; Nakayama, M; Nagisa, Y; Kasai, S; Maekawa, T Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test. Bioorg Med Chem 24:2504-18 (2016) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50163501
Synonyms:
CHEMBL3793001
Type:
Small organic molecule
Emp. Form.:
C20H16F3N3O2S
Mol. Mass.:
419.42
SMILES:
Cc1n(C)nc2ccc(cc12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O
Structure:
Search PDB for entries with ligand similarity: