Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50163878
Substrate
n/a
Meas. Tech.
ChEBML_1573812
Ki
396±n/a nM
Citation
 Tosh, DK; Ciancetta, A; Warnick, E; O'Connor, R; Chen, Z; Gizewski, E; Crane, S; Gao, ZG; Auchampach, JA; Salvemini, D; Jacobson, KA Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. J Med Chem 59:3249-63 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3AR | AA3R_MOUSE | Adenosine A3 receptor | Adora3 | Gpcr2
Type:
PROTEIN
Mol. Mass.:
36460.91
Organism:
Mus musculus
Description:
ChEMBL_1515686
Residue:
319
Sequence:
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADIAVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRAVRLCQTSDSLDSNMEQTTE
  
Inhibitor
Name:
BDBM50163878
Synonyms:
CHEMBL3799738
Type:
Small organic molecule
Emp. Form.:
C19H16ClN5O3S
Mol. Mass.:
429.88
SMILES:
[H][C@]12C[C@]1([C@@H](O)[C@@H](O)[C@@H]2n1cnc2cnc(nc12)C#Cc1ccc(Cl)s1)C(=O)NC |r|
Structure:
Search PDB for entries with ligand similarity: