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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50167989
Substrate
n/a
Meas. Tech.
ChEMBL_1574573 (CHEMBL3800856)
IC50
9400±n/a nM
Citation
 Zhu, S; Hao, X; Zhang, S; Qin, X; Chen, X; Zhu, C Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents. Bioorg Med Chem Lett 26:2880-2885 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50167989
Synonyms:
CHEMBL3798264
Type:
Small organic molecule
Emp. Form.:
C16H16N2O5S
Mol. Mass.:
348.374
SMILES:
OC(=O)CN1CN(Cc2ccccc2)S(=O)(=O)c2cc(O)ccc12
Structure:
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