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Target
Cyclin-C
Ligand
BDBM50264866
Substrate
n/a
Meas. Tech.
ChEMBL_1577630 (CHEMBL3807238)
IC50
3.0±n/a nM
Citation
 Koehler, MF; Bergeron, P; Blackwood, EM; Bowman, K; Clark, KR; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, MH Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. ACS Med Chem Lett 7:223-8 (2016) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50264866
Synonyms:
4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yloxy)biphenyl-4-carboxamide | CHEMBL491228
Type:
Small organic molecule
Emp. Form.:
C21H14N6O2S
Mol. Mass.:
414.44
SMILES:
NC(=O)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Structure:
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