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Target
D-amino-acid oxidase
Ligand
BDBM50170274
Substrate
n/a
Meas. Tech.
ChEMBL_1577590 (CHEMBL3807134)
IC50
520±n/a nM
Citation
 Xie, D; Lu, J; Xie, J; Cui, J; Li, TF; Wang, YC; Chen, Y; Gong, N; Li, XY; Fu, L; Wang, YX Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. Eur J Med Chem 117:19-32 (2016) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | D-amino-acid oxidase (DAAO) | DAMOX | DAO | OXDA_PIG
Type:
Flavoprotein
Mol. Mass.:
39338.01
Organism:
Sus scrofa (pig)
Description:
Homodimer.
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPYIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLTMPPSHL
  
Inhibitor
Name:
BDBM50170274
Synonyms:
CHEMBL3804949
Type:
Small organic molecule
Emp. Form.:
C8H4F3N3O2
Mol. Mass.:
231.1315
SMILES:
FC(F)(F)c1ccnc2[nH]c(=O)c(=O)[nH]c12
Structure:
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