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Target
Integrase
Ligand
BDBM50170913
Substrate
n/a
Meas. Tech.
ChEMBL_1578163 (CHEMBL3807245)
IC50
1360±n/a nM
Citation
 Billamboz, M; Suchaud, V; Bailly, F; Lion, C; Andréola, ML; Christ, F; Debyser, Z; Cotelle, P 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4. Eur J Med Chem 117:256-68 (2016) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50170913
Synonyms:
CHEMBL3805999
Type:
Small organic molecule
Emp. Form.:
C15H16N2O4
Mol. Mass.:
288.2985
SMILES:
ON1C(=O)C(C(=O)NC2CCCC2)c2ccccc2C1=O
Structure:
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