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Target
Proteasome subunit beta type-5
Ligand
BDBM50171079
Substrate
n/a
Meas. Tech.
ChEMBL_1576856 (CHEMBL3806500)
IC50
18700±n/a nM
Citation
 McDaniel, TJ; Lansdell, TA; Dissanayake, AA; Azevedo, LM; Claes, J; Odom, AL; Tepe, JJ Substituted quinolines as noncovalent proteasome inhibitors. Bioorg Med Chem 24:2441-50 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50171079
Synonyms:
CHEMBL3805403
Type:
Small organic molecule
Emp. Form.:
C15H20N2
Mol. Mass.:
228.3327
SMILES:
CCc1cc2cc(ccc2nc1CC)N(C)C
Structure:
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