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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50172062
Substrate
n/a
Meas. Tech.
ChEMBL_1577193 (CHEMBL3807567)
IC50
5480±n/a nM
Citation
 Yang, YS; Yang, B; Zou, Y; Li, G; Zhu, HL Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors. Bioorg Med Chem 24:3052-3061 (2016) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
Craf | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1_MOUSE | Raf-1 | Raf1
Type:
PROTEIN
Mol. Mass.:
72947.25
Organism:
Mus musculus
Description:
ChEMBL_116790
Residue:
648
Sequence:
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50172062
Synonyms:
CHEMBL3806108
Type:
Small organic molecule
Emp. Form.:
C25H25N3O2
Mol. Mass.:
399.4849
SMILES:
CN(C)c1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:12|
Structure:
Search PDB for entries with ligand similarity: