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Target
Sodium/nucleoside cotransporter 2
Ligand
BDBM50172400
Substrate
n/a
Meas. Tech.
ChEMBL_1579902 (CHEMBL3813158)
IC50
3300±n/a nM
Citation
 Tatani, K; Hiratochi, M; Kikuchi, N; Kuramochi, Y; Watanabe, S; Yamauchi, Y; Itoh, F; Isaji, M; Shuto, S Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout. J Med Chem 59:3719-31 (2016) [PubMed]  Article 
Target
Name:
Sodium/nucleoside cotransporter 2
Synonyms:
CNT2 | S28A2_HUMAN | SLC28A2
Type:
PROTEIN
Mol. Mass.:
71934.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1477251
Residue:
658
Sequence:
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
  
Inhibitor
Name:
BDBM50172400
Synonyms:
CHEMBL3808970
Type:
Small organic molecule
Emp. Form.:
C26H28N6O7
Mol. Mass.:
536.5365
SMILES:
COC(=O)COc1cc(CNc2nc3c(N)ncnc3n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1-c1ccccc1 |r|
Structure:
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