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TargetLarge neutral amino acids transporter small subunit 1
LigandBDBM50174345
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1579725
IC50 7300±n/a nM
Citation Augustyn, EFinke, KZur, AAHansen, LHeeren, NChien, HCLin, LGiacomini, KMColas, CSchlessinger, AThomas, AA LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorg Med Chem Lett26:2616-2621 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Large neutral amino acids transporter small subunit 1
Name:Large neutral amino acids transporter small subunit 1
Synonyms:4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:PROTEIN
Mol. Mass.:55013.61
Organism:Homo sapiens (Human)
Description:ChEMBL_100160
Residue:507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIV
GTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYM
LEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVL
LLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDV
GNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTL
STEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLP
SILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRH
RKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKN
KPKWLLQGIFSTTVLCQKLMQVVPQET
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  Blast E-value cutoff:
BDBM50174345
NameBDBM50174345
Synonyms:CHEMBL3809112
TypeSmall organic molecule
Emp. Form.C16H17NO2
Mol. Mass.255.3117
SMILESN[C@@H](Cc1cccc(Cc2ccccc2)c1)C(O)=O |r|
Structure
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