Reaction Details Report a problem with these data
Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ligand
BDBM50181526
Substrate
n/a
Meas. Tech.
ChEMBL_1585632 (CHEMBL3820451)
Kd
965±n/a nM
Citation
 Dennis, ML; Pitcher, NP; Lee, MD; DeBono, AJ; Wang, ZC; Harjani, JR; Rahmani, R; Cleary, B; Peat, TS; Baell, JB; Swarbrick, JD Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J Med Chem 59:5248-63 (2016) [PubMed]  Article 
Target
Name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase | HPPK | HPPK_ECOLI | JW0138 | PPPK | folK
Type:
PROTEIN
Mol. Mass.:
18075.55
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_108237
Residue:
159
Sequence:
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
  
Inhibitor
Name:
BDBM50181526
Synonyms:
CHEMBL3818561
Type:
Small organic molecule
Emp. Form.:
C13H12FN5OS
Mol. Mass.:
305.331
SMILES:
Cc1ccc(F)c(CSc2nc3c(nc(N)[nH]c3=O)[nH]2)c1
Structure:
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