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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50182421
Substrate
n/a
Meas. Tech.
ChEMBL_1584540 (CHEMBL3820395)
IC50
2.4±n/a nM
Citation
 Woolford, AJ; Pero, JE; Aravapalli, S; Berdini, V; Coyle, JE; Day, PJ; Dodson, AM; Grondin, P; Holding, FP; Lee, LY; Li, P; Manas, ES; Marino, J; Martin, AC; McCleland, BW; McMenamin, RL; Murray, CW; Neipp, CE; Page, LW; Patel, VK; Potvain, F; Rich, S; Rivero, RA; Smith, K; Somers, DO; Trottet, L; Velagaleti, R; Williams, G; Xie, R Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J Med Chem 59:5356-67 (2016) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50182421
Synonyms:
CHEMBL3817896
Type:
Small organic molecule
Emp. Form.:
C23H29N3O3S
Mol. Mass.:
427.56
SMILES:
COC(CO)Cc1csc(Nc2cc(c(C)cc2OCCN)-c2ccccc2C)n1
Structure:
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