Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM50184951
Substrate
n/a
Meas. Tech.
ChEMBL_1587988 (CHEMBL3824742)
IC50
199±n/a nM
Citation
 Li, DD; Chen, WL; Xu, XL; Jiang, F; Wang, L; Xie, YY; Zhang, XJ; Guo, XK; You, QD; Sun, HP Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5. Eur J Med Chem 118:1-8 (2016) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50184951
Synonyms:
CHEMBL3823328
Type:
Small organic molecule
Emp. Form.:
C26H24ClFN4O
Mol. Mass.:
462.946
SMILES:
CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(cc1)C#N
Structure:
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