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Target
Histone deacetylase 3
Ligand
BDBM50189911
Substrate
n/a
Meas. Tech.
ChEMBL_1591003 (CHEMBL3830981)
IC50
2280±n/a nM
Citation
 Wagner, FF; Weïwer, M; Steinbacher, S; Schomburg, A; Reinemer, P; Gale, JP; Campbell, AJ; Fisher, SL; Zhao, WN; Reis, SA; Hennig, KM; Thomas, M; Müller, P; Jefson, MR; Fass, DM; Haggarty, SJ; Zhang, YL; Holson, EB Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem 24:4008-4015 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50189911
Synonyms:
CHEMBL3827611
Type:
Small organic molecule
Emp. Form.:
C20H21FN2O2
Mol. Mass.:
340.3913
SMILES:
[H][C@]12CC[C@]([H])(C[C@H](C1)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1)O2 |r|
Structure:
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