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Target
DNA polymerase kappa
Ligand
BDBM50191327
Substrate
n/a
Meas. Tech.
ChEMBL_1612840 (CHEMBL3854640)
IC50
13000±n/a nM
Citation
 Korzhnev, DM; Hadden, MK Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics. J Med Chem 59:9321-9336 (2016) [PubMed]  Article 
Target
Name:
DNA polymerase kappa
Synonyms:
DINB1 | POLK | POLK_HUMAN
Type:
PROTEIN
Mol. Mass.:
98825.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1297316
Residue:
870
Sequence:
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
  
Inhibitor
Name:
BDBM50191327
Synonyms:
CHEMBL3960997
Type:
Small organic molecule
Emp. Form.:
C28H37ClO2S
Mol. Mass.:
473.11
SMILES:
CC(C)c1ccc2C(Cc3ccc(Cl)cc3)C(CC(C)(C)C(O)=O)C(SC(C)(C)C)c2c1
Structure:
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