Target
5'-AMP-activated protein kinase subunit beta-2
Ligand
BDBM237920
Substrate
n/a
Meas. Tech.
ChEMBL_1612904 (CHEMBL3854704)
EC50
>40000±n/a nM
Citation
 Cameron, KOKung, DWKalgutkar, ASKurumbail, RGMiller, RSalatto, CTWard, JWithka, JMBhattacharya, SKBoehm, MBorzilleri, KABrown, JACalabrese, MCaspers, NLCokorinos, EConn, ELDowling, MSEdmonds, DJEng, HFernando, DPFrisbie, RHepworth, DLandro, JMao, YRajamohan, FReyes, ARRose, CRRyder, TShavnya, ASmith, ACTu, MWolford, ACXiao, J Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J Med Chem 59:8068-81 (2016) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase subunit beta-2
Synonyms:
AAKB2_HUMAN | AMPK alpha2/beta2/gamma3 | AMPK subunit beta-2 | PRKAB2
Type:
PROTEIN
Mol. Mass.:
30301.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107883
Residue:
272
Sequence:
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM237920
Synonyms:
US9394285, 1
Type:
Small organic molecule
Emp. Form.:
C19H16ClNO3
Mol. Mass.:
341.788
SMILES:
OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1
Structure:
Search PDB for entries with ligand similarity: