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TargetCyclin-C
LigandBDBM50191472
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1613001
IC50 1.4±n/a nM
Citation Czodrowski, PMallinger, AWienke, DEsdar, CPöschke, OBusch, MRohdich, FEccles, SAOrtiz-Ruiz, MJSchneider, RRaynaud, FIClarke, PAMusil, DSchwarz, DDale, TUrbahns, KBlagg, JSchiemann, K Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. J Med Chem59:9337-9349 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-C
Name:Cyclin-C
Synonyms:CCNC | Cyclin C | SRB11 homolog | hSRB11
Type:PROTEIN
Mol. Mass.:33244.88
Organism:Homo sapiens (Human)
Description:ChEMBL_107900
Residue:283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50191472
NameBDBM50191472
Synonyms:CHEMBL3956719
TypeSmall organic molecule
Emp. Form.C19H18ClN3O
Mol. Mass.339.819
SMILESCc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a