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Target
Chromobox protein homolog 8
Ligand
BDBM50194468
Substrate
n/a
Meas. Tech.
ChEMBL_1616629 (CHEMBL3858698)
IC50
>60000±n/a nM
Citation
 Stuckey, JI; Simpson, C; Norris-Drouin, JL; Cholensky, SH; Lee, J; Pasca, R; Cheng, N; Dickson, BM; Pearce, KH; Frye, SV; James, LI Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains. J Med Chem 59:8913-8923 (2016) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 8
Synonyms:
CBX8 | CBX8_HUMAN | PC3 | Polycomb 3 homolog | RC1 | Rectachrome 1 | hPc3
Type:
PROTEIN
Mol. Mass.:
43415.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108272
Residue:
389
Sequence:
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
  
Inhibitor
Name:
BDBM50194468
Synonyms:
CHEMBL3966329
Type:
Small organic molecule
Emp. Form.:
C42H61N7O9
Mol. Mass.:
807.9752
SMILES:
COC(=O)[C@H](CO)NC(=O)[C@H](CCCCN1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c1ccccc1 |r|
Structure:
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