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Target
Renin
Ligand
BDBM50354357
Substrate
n/a
Meas. Tech.
ChEMBL_1617704 (CHEMBL3859773)
IC50
>300000±n/a nM
Citation
 Tawada, M; Suzuki, S; Imaeda, Y; Oki, H; Snell, G; Behnke, CA; Kondo, M; Tarui, N; Tanaka, T; Kuroita, T; Tomimoto, M Novel approach of fragment-based lead discovery applied to renin inhibitors. Bioorg Med Chem 24:6066-6074 (2016) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50354357
Synonyms:
CHEMBL1836471 | DT2000-0142665, MAP03
Type:
Small organic molecule
Emp. Form.:
C10H11N3S
Mol. Mass.:
205.279
SMILES:
Nc1ncnc2sc3CCCCc3c12
Structure:
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