Reaction Details
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Lysophosphatidic acid receptor 1
Ligand
BDBM50195693
Substrate
n/a
Meas. Tech.
ChEMBL_1617900 (CHEMBL3859969)
IC50
42±n/a nM
Citation
Terakado, M; Suzuki, H; Hashimura, K; Tanaka, M; Ueda, H; Kohno, H; Fujimoto, T; Saga, H; Nakade, S; Habashita, H; Takaoka, Y; Seko, T Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead. ACS Med Chem Lett 7:913-918 (2016) [PubMed] Article More Info.:
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
Inhibitor
Name:
BDBM50195693
Synonyms:
CHEMBL3947597
Type:
Small organic molecule
Emp. Form.:
C34H35NO6
Mol. Mass.:
553.6448
SMILES:
COc1cc(cc(OC)c1C)C(=O)N(CCCc1ccccc1)Cc1ccc(Oc2ccc(C)cc2C(O)=O)cc1
Structure:
