Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50129062
Substrate
n/a
Meas. Tech.
ChEMBL_1617948 (CHEMBL3860117)
KOFF
0.346300 s-1
Citation
 Lund, BA; Christopeit, T; Guttormsen, Y; Bayer, A; Leiros, HK Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. J Med Chem 59:5542-54 (2016) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | OXA-48 | Synonyms=blaOXA-48 | bla
Type:
PROTEIN
Mol. Mass.:
30363.94
Organism:
Klebsiella pneumoniae
Description:
ChEMBL_103606
Residue:
265
Sequence:
MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
  
Inhibitor
Name:
BDBM50129062
Synonyms:
CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Merrem iv | SM-7338
Type:
Small organic molecule
Emp. Form.:
C17H25N3O5S
Mol. Mass.:
383.463
SMILES:
[H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H] |r,t:11|
Structure:
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