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TargetAurora kinase A/Targeting protein for Xklp2
LigandBDBM50198044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1620440
IC50 25±n/a nM
Citation Kilchmann, FMarcaida, MJKotak, SSchick, TBoss, SDAwale, MG÷nczy, PReymond, JL Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J Med Chem59:7188-211 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A/Targeting protein for Xklp2
Name:Aurora kinase A/Targeting protein for Xklp2
Synonyms:ARK1 | AURKA | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50198044
NameBDBM50198044
Synonyms:CHEMBL3903187
TypeSmall organic molecule
Emp. Form.C25H22N8OS
Mol. Mass.482.56
SMILESCCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cc3)-c3nnn[nH]3)c2)C(=O)N1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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