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Target
DNA polymerase lambda
Ligand
BDBM50198198
Substrate
n/a
Meas. Tech.
ChEMBL_1620506 (CHEMBL3862789)
IC50
5600±n/a nM
Citation
 Le, DH; Nishimura, K; Takenaka, Y; Mizushina, Y; Tanahashi, T Polyprenylated Benzoylphloroglucinols with DNA Polymerase Inhibitory Activity from the Fruits of Garcinia schomburgkiana. J Nat Prod 79:1798-807 (2016) [PubMed]  Article 
Target
Name:
DNA polymerase lambda
Synonyms:
DNA polymerase lambda (Pol λ) | DPOLL_HUMAN | POLL
Type:
Protein
Mol. Mass.:
63493.10
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
575
Sequence:
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
  
Inhibitor
Name:
BDBM50198198
Synonyms:
CHEMBL3889506
Type:
Small organic molecule
Emp. Form.:
C43H58O7
Mol. Mass.:
686.9164
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](/[#6])-[#6]\[#6]=[#6]\C([#6])([#6])[#8])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:28,TLB:49:48:20.8.6:29.27.40|
Structure:
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