Reaction Details Report a problem with these data
Target
Microtubule-associated protein tau
Ligand
BDBM50198629
Substrate
n/a
Meas. Tech.
ChEBML_1620755
IC50
1200±n/a nM
Citation
 Okuda, M; Hijikuro, I; Fujita, Y; Teruya, T; Kawakami, H; Takahashi, T; Sugimoto, H Design and synthesis of curcumin derivatives as tau and amyloidß dual aggregation inhibitors. Bioorg Med Chem Lett 26:5024-5028 (2016) [PubMed]  Article 
Target
Name:
Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein
Type:
Protein
Mol. Mass.:
78928.63
Organism:
Homo sapiens (Human)
Description:
P10636
Residue:
758
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM50198629
Synonyms:
CHEMBL3978488
Type:
Small organic molecule
Emp. Form.:
C21H18O6
Mol. Mass.:
366.364
SMILES:
COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc3OCOc3c2)ccc1O
Structure:
Search PDB for entries with ligand similarity: