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Target
C-C chemokine receptor type 10
Ligand
BDBM50198997
Substrate
n/a
Meas. Tech.
ChEMBL_1621016 (CHEMBL3863299)
IC50
10.0±n/a nM
Citation
 Abeywardane, A; Caviness, G; Choi, Y; Cogan, D; Gao, A; Goldberg, D; Heim-Riether, A; Jeanfavre, D; Klein, E; Kowalski, JA; Mao, W; Miller, C; Moss, N; Ramsden, P; Raymond, E; Skow, D; Smith-Keenan, L; Snow, RJ; Wu, F; Wu, JP; Yu, Y N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett 26:5277-5283 (2016) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 10
Synonyms:
C-C CKR-10 | C-C chemokine receptor type 10 | CC-CKR-10 | CCR-10 | CCR10 | CCR10_HUMAN | G-protein coupled receptor 2 | GPR2
Type:
PROTEIN
Mol. Mass.:
38433.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105617
Residue:
362
Sequence:
MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
  
Inhibitor
Name:
BDBM50198997
Synonyms:
CHEMBL3971826
Type:
Small organic molecule
Emp. Form.:
C22H25N5O3S
Mol. Mass.:
439.531
SMILES:
O=C(C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12)N1CCCCC1
Structure:
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