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Target
Proteasome subunit beta type-5
Ligand
BDBM50200509
Substrate
n/a
Meas. Tech.
ChEMBL_1622284 (CHEMBL3864636)
IC50
3.0±n/a nM
Citation
 Zhang, J; Gao, L; Xi, J; Sheng, L; Zhao, Y; Xu, L; Shao, Y; Liu, S; Zhuang, R; Zhou, Y; Li, J Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors. Bioorg Med Chem 24:6206-6214 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50200509
Synonyms:
CHEMBL3890040
Type:
Small organic molecule
Emp. Form.:
C40H44ClN5O4
Mol. Mass.:
694.261
SMILES:
Clc1ccccc1CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)N1CCC(CC1)C(=O)Nc1ccccc1 |r|
Structure:
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