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TargetNicotinamide phosphoribosyltransferase
LigandBDBM50202721
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1624778
IC50 0.400000±n/a nM
Citation Zak, MYuen, PWLiu, XPatel, SSampath, DOeh, JLiederer, BMWang, WO'Brien, TXiao, YSkelton, NHua, RSodhi, JWang, YZhang, LZhao, GZheng, XHo, YCBair, KWDragovich, PS Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. J Med Chem59:8345-68 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM50202721
NameBDBM50202721
Synonyms:CHEMBL3968268
TypeSmall organic molecule
Emp. Form.C24H34N4O3
Mol. Mass.426.5518
SMILESCC1(CC(=O)N2CCC3(CC3CNC(=O)N3Cc4ccncc4C3)CC2)CCOCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a