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Target
Free fatty acid receptor 1
Ligand
BDBM50203654
Substrate
n/a
Meas. Tech.
ChEMBL_1625793 (CHEMBL3868262)
EC50
1042±n/a nM
Citation
 Lombardo, M; Bender, K; London, C; Plotkin, MA; Kirkland, M; Mane, J; Pachanski, M; Geissler, W; Cummings, J; Habulihaz, B; Akiyama, TE; Di Salvo, J; Madeira, M; Pols, J; Powles, MA; Finley, MF; Johnson, E; Roussel, T; Uebele, VN; Crespo, A; Leung, D; Alleyne, C; Trusca, D; Lei, Y; Howard, AD; Ujjainwalla, F; Tata, JR; Sinz, CJ Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. Bioorg Med Chem Lett 26:5724-5728 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50203654
Synonyms:
CHEMBL3968947
Type:
Small organic molecule
Emp. Form.:
C17H14ClF3O4
Mol. Mass.:
374.739
SMILES:
OC(=O)CCCOc1ccc(cc1)-c1cc(OC(F)(F)F)ccc1Cl
Structure:
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